4M Knowledge base - papers

B. Ahmed-Omera (b), D. Barrow (b), T. Wirth (a)

(a) Cardiff School of Chemistry, Cardiff University, Cardiff, CF10 3AT, UK
(b) Laboratory for Applied Microsystems, Cardiff School of Engineering, Cardiff University, Cardiff, CF24 3TF, UK

Abstract

The contact between immiscible liquids in a microfluidic system creating segmented flow offers great potential in the study of biphasic reactions in organic chemistry with significant advantages with respect to conventional flask techniques. As organic solvents play a key role in many chemical processes within the pharmaceutical and chemical industry, there are many applications of biphasic reactions in different areas of chemistry. For a simple biphasic reactions, we show that the application of various reaction conditions in microreactors using segmented flow can dramatically increase the reaction rate, especially when microwave irradiation, sonication or phase transfer catalysis
are combined with segmentation.